脉络宁对COPD患者ET含量的变化观察

Effect of Chronic Maluoling Treatment on Plasma Contents of ET in Patients with COPD

目的:探讨脉络宁对慢性阻塞性肺病(chronic obstructive pulmonary diseases,COPD)患者血浆内皮素(endothelin,ET)含量变化的影响。方法:选择COPD患者45例在脉络宁应用前及一年时分别测定血浆ET含量为观察组;同期未应用脉络宁的COPD患者为对照组,同时测定ET含量。采用放免法(RIA)测定血浆ET含量。结果:观察组由治疗前(80.49±29.67)pg/ml至一年时(64.38±24.5)pg/ml;对照组(78.28±24.38)pg/ml至一年时(77.49±30.63)pg/ml。二组治疗前对比无差异(P>0.05)。应用后,一年时对比有显著性差异(P<0.05)。结论:脉络宁对COPD患者具有调节血浆ET使其减少的作用。

Objective To study the effect of maluoling treatment on plasma ET eonents in patients with COPD. Methods Plasma ET contents were measured with RIA at admission one year later in （1） 45 patients with COPD treated with 4 courses of maluoling and （2） 82 patients with COPD without maluoling treatment. Results The plasma ET contents in the two groups of COPD patients were not much different at admission （80.49 ± 29.67pg/ml vs 78.28 ± 24.38pg/ml, P 〉 0.05）. One year later, the plasma ET contents in the 45 patients with maluoling treatment were significantly lower than those in the 32 patients without maluoling treatment （64.38 ± 24. 52pg/ml vs 77.49 ± 30.63pg/ml, P 〈 0.05）. Conclusion Chronic use of maluoling could markedly decrease the plasma ET contents in patients with COPD.