血小板相关抗体检测的应用价值

Clinical Value of Detection of Serum Platelet-Associatcd Immunoglobulin

目的:探讨血小板相关抗体(PAIgG)检测的应用价值。方法:采用流式细胞术分别对42例特发性血小板减少性紫癜(ITP)患者、39例再生障碍性贫血患者及21例其他自身免疫性疾病患者的PAIgG进行检测,并分析其与血小板输注无效率的关系。结果:ITP患者组、再生障碍性贫血患者组及其他自身免疫性疾病患者组PAIgG阳性血小板百分率均明显高于正常对照组(P<0.01);PAIgG阳性的ITP患者及再生障碍性贫血患者中的血小板输注无效率均明显高于PAIgG阴性的患者(P<0.01,P<0.05)。结论:PAIgG用于ITP诊断敏感性高,特异性差,PAIgG的存在与血小板输注无效存在密切关系,是引起血小板输注无效的重要原因之一。

Objective To observe the clinical significance of detection of serum platelet - associated immtmoglobulin（PAIgG）. Methods Flow eytometry was used to detect serum PAIgG in 42 patients with idiopathic throbocytopenic purpura（ITP） , 39 patients with aplastie anemia（AA） , 21 patients with other autoimmtme diseases and 35 controls. Percentage of inefficient platelet infusion was calculated. Results Positive rates of PAIgG in ITP, AA and other autoimmtme diseases were higher than that in controls （P 〈 0.01 ）. Percentages of inefficient platelet infusion in PAIgG positive ITP and AA patients were higher than those in PAIgG negative patients （P 〈 0.01, P 〈 0.05）. Conclusion PAIgG is a sensitive but not specific marker for ITP diagnosis. PAIgG positive is an important cause for inefficient platelet infusion.