女性2型糖尿病患者的骨密度变化

Changes of Bone Mineral Density in Female Patients with Type 2 Diabetes

目的:探讨女性2型糖尿病与骨质疏松的关系。方法:应用双能X线骨密度仪(DEXA)对56例女性2型糖尿病患者及52例女性健康对照者进行骨密度(BMD)测定,并测定糖尿病患者的空腹胰岛素及餐后2h胰岛素(2h Ins)水平,结合病程、年龄等相关因素进行分析。结果:52例健康对照组中低骨量8例,骨质疏松5例,骨密度减低的发生率为25%;56例2型糖尿病患者中,低骨量16例,骨质疏松23例,骨密度减低的发生率为69.7%,明显高于对照组,差异有显著性(P<0.01,χ2=21.524),骨密度减低者胰岛素水平相对更低。结论:女性2型糖尿病患者的骨质疏松发生率高,且与年龄、病程、胰岛素水平相关。

Objective To study the relationship between the development of osteoporosis and type 2 diabetes mellitns in female patients. Methods Bone mineral density （BMD） was measured with dual energy X- ray absorptiometry （DEXA） and fasting, 2h postprandial serum insulin levels （ with ECLIA） in 56 female diabetic patients and 52 controls. Results Among the 56 female diabetics, 23 could be defined as with osteoporosis another 16 patients were with bone mass less than normal, so there were altogether 39 patients with decreased BMD （69.7%）. The corresponding figures in the 52 controls were 5 and 8 （25%）. Difference between the two groups （69.7% vs 25 % ） was sigrfifieant （ P 〈 0.01 ）. Lower bone density was associated with lower fasting and 2h post prandial insulin level. Conclusion Female patients with type 2 diabetes mellitns were prone to develop osteoporosis. Reduction of BMD was associated with old age, long history of diabetes and low insulin levels.