老年冠心病血浆抵抗素与胰岛素抵抗相关性

Relationship between Plasma Resistin and Insulin Resistance in Old Hypertension Patients

目的了解老年冠心病患者血浆抵抗素水平与胰岛素抵抗的关系。方法选择31例中青年人(对照组)和49例老年人(老年组),分别为冠心病亚组和健康老人亚组,用竞争性酶联免疫吸附试验测定各组空腹血浆抵抗素水平,同时测定空腹血糖、空腹胰岛素、血脂和胰岛素敏感指数,测量受试对象腰围、臀围和腰臀比。结果老年组血浆抵抗素水平和对照组相比明显升高(P<0.05),老年组中冠心病亚组血浆抵抗素与健康老人亚组相比差异无统计学意义。抵抗素与年龄呈正相关(r=0.31,P<0.01;r=0.28,P<0.05),与体质指数呈正相关(r=0.25,P<0.05),与胰岛素抵抗指数呈负相关(r=-0.31,P<0.05),但在各实验组中,抵抗素与体质指数无明显相关性。结论空腹血浆抵抗素水平与年龄和体质指数呈正相关,与胰岛素抵抗指数呈负相关。

Objective To find out the relationship between plasma resistin and insulin resistance in old hypertension patients. Methods 31 young persons（the Control Group） and 49 old persons（the Elderly Group） were divided into hypertension group and normal group respectively. Plasma resistin was determined by ELISA, meanwhile, FBG, fasting insulin, blood lipid and insulin sensitive index were examined in each groups. Waistline, hip circumference and WHR（ waist-to-hip ratio） of each person were measured. Results Compare with the control group, the plasma resistin level of the elderly group was obviously elevatory （ P〈0.05 ）. In elder group, the difference of plasma resistin between hypertension group and normal group was insignificant;Plasma resistin had positive correlation with ages （ r = 0.3 l, P〈0.01 ; r = 0.28, P〈0.05 ）, constitution index （ r = 0.25, P〈0.05 ） and had negative correlation with insulin resistance index（ r = -0.31 ,P〈0.05 ） ;But there had no correlation between resistin and constitutional indexin in each group. Conclusions Fasting plasma resistin level has a positive correlation with constitution index and has a negative correlation with insulin resistance index.