1200例解脲脲原体感染及其药敏试验分析

Analysis of Ureaplasma urealyticum infection situation and drug sensitivity test in 1200 patients

目的探讨解脲脲原体(UU)的临床感染和耐药情况,指导临床合理用药。方法利用支原体鉴定药敏检测试剂盒进行临床检测。结果2 532例受检者中共有1200例解脲脲原体培养结果阳性,阳性率为47.4%,其中男性感染者349例,阳性率为30.0%;女性感染者851例,阳性率为62.1%。药敏结果显示,12种抗生素中以交沙霉素和美满霉素敏感性最强,强力霉素、四环素、克拉霉素次之,而对氧氟沙星、红霉素、环丙沙星敏感性较差。结论UU引起的感染日趋增多,治疗UU感染应根据药敏试验结果选择敏感、有效的抗生素。

Objective The aim of the study was to investigate the infection situation and drug resistance of Ureaplasma urealyticum （UU）, and to guide the rational use of antibacterial agents in clinic. Methods Mycoplasma identification kit was applied to the clinical determination and drug resistance analysis of Ureaplasma urealyticum. Results A total of 1 200 cases （47.4%） were UU positive in 2 532 cases. Among the 1 200 cases, 349 cases （30.0%） were males, and 851 cases （62.1%） were females. The drug sensitivity to josamycin and minocycline was the highest, followed by deoxycycline, ambramycin and clarithromycin. The sensitivity to ofloxacin, erythromycin and ciprofloxacin was lower. Conclusion The infected rate of UU is rising in recent years. Sensitive and effective antibiotics should be selected to treat UU infection according to drug sensitivity test.