应用头孢类抗生素治疗期间饮酒致双硫醒反应16例

16 cases with the abstinyl reaction caused by drinking while using the cephalosporin antibiotic

目的:研究输注或口服头孢类抗生素后饮酒出现双硫醒反应的发病机制,为防止再次出现此反应提供依据。方法:对16例出现双硫醒反应的病例进行临床分析。结果:乙醛在体内蓄积致双硫醒反应,引起一系列临床症状与体征:面色潮红、出汗、胸闷、心悸、气短感,心电图示窦性心动过速等;经对症治疗后病情可缓解。结论:应高度重视输注或口服头孢类抗生素后饮酒出现的双硫醒反应,在应用头孢类抗生素期间或停药后1周内避免饮酒。

Objective： To study the pathogenesis of abstinyl reaction caused by drinking while infecting or taking orally the cephalosporin antibiotic. Preventing the recurrence of such reaction and providing a basis for the reaction. Methods：Clinical analysis of the 16 cases with abstinyl reaction. Results： The pathogenesis was that the ethyl alcohol stores up in the body and causes a series of clinical symptoms and signs, such as facial flushing, sweating, chest stuffiness, palpitation, panting, electrocardiogram showing Dou tachycardia and so on. We could alleviate the illness by symptomatic treatment. Conclusion： We should attach great importance to the reaction and avoid drinking while using the cephalosporin antibiotic or after the drug withdrawal within a week.