山里红叶提取物抗脂肪肝作用研究

Study on the Antifatty Liver of the Extract of the Leaves of Crataegus Pinnatifida Bge. var. major

目的:研究筛选山里红叶抗高血脂性脂肪肝活性部位。方法:采用高血脂脂肪肝模型,模型组与正常组及给药组在生理状况、肝体比计算、生化检测指标(TC、TG)及肝脂变率进行比较,并结合肝脏病理检查研究山里红叶提取物抗脂肪肝作用。结果:模型组与正常组及各给药组比较,肝体比(P<0.05)有显著性差异,血清总胆固醇及甘油三酯均高于正常组(P<0.05),给药组肝脏病理学检查有明显改善。结论:山里红叶70%乙醇提取的正丁醇部位有明显抗脂肪作用。

Objective ： Screen the active part of antifatty liver of the leaves of Crataegus pinnatifida Bge. var. major. Methods ： A composite model of hyperlipemia of rat was established to study the pharmaeological function of the extract of the leaves of Crataegus pinnatifida Bge. var. major,and the results of experiment were analyzed using one-way ANOVA. Results ： The extract remarkably affected the results of TC, TC ,the ratio of liver- body weight and pathological examination. Conclusion ： The extract of 70% ethanol was loaded on porous polymer resin column, and the n - Butanol fraction of the elute was established to be the optimal active part.