颈动脉粥样硬化患者血清基质金属蛋白酶-9水平、颈动脉斑块及其与人巨细胞病毒感染的关系

Relationship between serum level of matrix metalloproteinases-9, carotid plaque and human cytomegalovirus infection in patients with carotid atherosclerosis

目的探讨颈动脉粥样硬化(CAS)患者基质金属蛋白酶(MMP)-9水平、颈动脉斑块及其与人巨细胞病毒(HCMV)感染的相关性。方法对90例CAS患者的HCMV-PP65抗原、血清MMP-9水平和颈动脉彩色多普勒超声检测结果进行分析和比较。结果(1)HCMV阳性(A组)、HCMV阴性(B组)及正常对照者(C组)血清MMP-9含量分别为(260.25±89.03)pg/ml、(157.47±78.28)pg/ml、(138.65±80.73)pg/ml,A组显著高于B组与C组(均P<0.01);B组及C组间差异无统计学意义。(2)A组颈动脉不稳定斑块检出率为81.25%(39/48),软斑积分为(2.905±0.768)分,显著高于B组[59.52%(25/42),(1.750±0.463)分](均P<0.05);A组硬斑积分[(2.273±0.647)分]与B组[(2.364±0.658)分]比较差异无统计学意义。结论CAS伴HCMV-PP65抗原阳性患者血清MMP-9水平明显增高,CAS斑块检出率高,且更具不稳定性。

Objective To study the relationship between the serum level of matrix metalloproteinases-9 （MMP- 9 ） ,carotid plaque and human cytomegalovirus （HCMV） infection in the patients with carotid atherosclerosis （CAS）. Methods The antigen of HCMV-PP65, serum level of MMP-9 and the results of coloured doppler sonography from 90 cases with CAS were analyzed and compared. Results （ 1 ） The contents of MMP-9 in antigen of HCMV-PP65 positive （A） group, negative （B） group and normal control （C） group was （260.25 ±89.03）pg/ml, （157.47 ± 78.28 ） pg/ml and （ 138.65 ± 80.73 ） pg/ml, respectively. Group A was significant higher than groups B and C （ all P 〈0. 01 ）. There was no significant difference between groups B and C. （2）The detection rate of instability plaque （81.25%） and soft plaque score （2.905 ±0.768） in group A were significant higher than those of group B （59. 52%, 1. 750 ± 0.463 ） （ all P 〈 0. 05 ）. The hard plaque score was 2.273 ± 0.647 in group A and 2. 364 ± 0.658 in group B. There was no significant difference between the two groups. Conclusions In CAS patients with positive antigen of HCMV-PP65, the content of MMP-9 and detection rate of instability plaque are significant higher. The plaques in these patients are more instable.