对氧磷酶2 G148A基因多态性与脑梗死的关系

Association between paraoxonase2 G148A genetic polymorphism and cerebral infarction

目的探讨对氧磷酶2(PON2)基因多态性与脑梗死(CI)的关系。方法用聚合酶链反应-限制性片段长度多态性分析法(PCR-RFLP)检测PON2 G148A基因多态性在CI组和健康对照组的基因型和等位基因频率;同时测定CI组的血脂、血糖。结果CI组患者PON2基因G148A的基因型和等位基因频率与健康对照组相比差异无统计学意义(均P>0.05);CI组各基因型及等位基因频率间的血脂、血糖比较均无统计学意义。结论CI患者PON2基因第148位密码子的多态性可能与CI的发生无关。

Objective To investigate the association between the G148A polymorphism of paraonase2 （PON2） gene and cerebral infarction （Ci） in Chinese. Methods Genotype and allele frequency of PON2 G148A polymorphism were studied by polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） analysis in CI group and healthy control group. Serum lipids and blood sugar（FBS） from CI patients were measured at the same time. Results There were no significant differences in genotype and allele frequency of PON2 G148A polymorphism between CI group and control group （all P 〉 0.05）. No significant differences were found in TC, TG and FBS among the subgroups which were divided according to different genotype and allele frequency of PON2 gene in the patients with CI. Conclusion G148A polymorphism of PON2 gene is not associated with CI.