用于犬剩余牙槽嵴重建的个性化β-磷酸三钙支架的制备与性能研究

Fabrication and physical properties of porous individual β-TCP scaffold to reconstruct residual alveolar ridge in dog

目的:制作用于剩余牙槽嵴重建的个性化β-磷酸三钙支架,并对其性能进行研究。方法:构建犬下颌骨局部剩余牙槽嵴模型,3个月后行CT扫描。三维重建后,利用快速成形技术制作树脂模型,在模型上用硅橡胶重建剩余牙槽嵴,得到模拟支架,翻制模拟支架的阴模。相同烧结条件下制备个性化β-磷酸三钙多孔支架和5个测试试样,烧结后,观察多孔支架的精确性。测定试样孔隙率、吸水率、抗压强度,并利用X射线衍射(XRD)分析其晶相,扫描电镜下观测其孔隙结构。结果:制得与剩余牙槽嵴树脂模型形态吻合的个性化支架。试样孔隙率为74%,吸水率为48%,抗压强度为4MPa,主晶相为β-磷酸三钙,内部孔径150～400μm,孔隙连通径40μm。结论:应用快速成形技术结合传统工艺成功制备了与剩余牙槽嵴形态匹配的个性化β-磷酸三钙支架。

PURPOSE： To fabricate porous individual β-tricalcium phosphate scaffold and test its properties in dog. METHODS： A model of residual alveolar ridge in mandible of a dog was made and CT scanned after 3 months.The data of CT was transformed to 3-D format by MIMICS 7.0 and was made to resin model by rapid prototype technique.The residual alveolar ridge was reconstructed using silicon rubber, and its impression was made.Porous individual β-tricalcium phosphate scaffold and 5 samples were fabricated for precision and properties test.Porosity, water absorbing capacity and compressive strength of samples were tested with crystalling phase and pore structure were analysed by XRD and scanning electron microscope. RESULTS： We successfully fabricated a scaffold which fit the resin model well and consisted of β- TCP.Its porosity was 74%,water absorbing capacity was 48%,compressive strength was 4MPa,diameter of pore was 150 to 400μm,connecting diameter was 40μm. CONCLUSIONS： We can fabricate individual β-TCP scaffold which fit the model well by combination of traditional method and rapid prototype technique.