单纯性高热惊厥脑损伤患儿血清NSE和PRL水平变化的临床意义

Clinical Significance of Changes of Serum NSE and PRL Levels on Brain Lesion in Simple Febrile Convulsion Children

目的检测单纯性高热惊厥(SFC)患儿血清神经元特异性烯醇化酶(NSE)、泌乳素(PRL)水平的变化,以探讨其对SFC患儿脑损伤的临床检测意义.方法选取我院儿科2006年1月至2006年6月确诊为SFC的35例患儿为实验组,同期发热无惊厥既往也无惊厥史的患儿23例为对照组1,21例健康体检儿童为对照组2,采用酶联免疫吸附测定法检测血清NSE、PRL含量.结果(1)实验组NSE水平与对照组1及对照组2比较,P<0.05,差异有统计学意义;对照组1与对照组2比较P>0.05,差异无统计学意义;(2)3组血清PRL比较,P>0.05,差异无统计学意义.结论SFC发作时血清NSE明显升高,血清NSE水平有望作为SFC脑损伤的血清学检测指标;PRL无明显变化,表明SFC与癫痫发作是有区别的.

Objective To explore the clinical detecting significance of the changes of serum neuron specific enolase （NSE） and prolactin （PRL） levels on brain lesion in children with simple febrile convulsion （SFC）. Methods 35 children who were diagnosed with SFC in our hospital during January to June in 2006 were chosen as experimental group, 23 children with fever but without convulsion in the same period as control group 1 and 21 healthy children as control group 2. ELISA detecting method was applied to detect NSE and PRL Results （ 1 ） Compared with those in control group 1 and 2, the serum NSE levels in experimental group （P〈0.05） was significantly different （P〈0.05）, but there was no visible difference between control group 1 and 2 （P〉0.05 ）. （2） To compare serum PRL levels, there was no statistical significance among three groups （P〉0.05）. Conclusion The serum level of NSE was obvious high but the serum PRL did not change in SFC group, so it is concluded that SFC could lead to brain lesion and serum NSE level can be used as an detecting index of brain lesion. The serum PRL level is useful for distinguishing diagnoses of convulsion.