变应性鼻炎和哮喘是一种疾病的临床调查研究

Evidences from clinical epidemiological survey for the concept of allergic rhinitis and asthma as one disease

目的从临床流行病学角度探讨变应性鼻炎和哮喘的相关性,进一步论证二者是一种疾病的概念。方法在3210例哮喘患者进行变应性鼻炎和哮喘的相关性调查,其中1960例患者中进行变应原皮内试验,1250例患者进行点刺试验。结果哮喘患者中伴有变应性鼻炎者2684例(83.61%),2402例先发生或同时发生变应性鼻炎(74.83%)。大部分变应性鼻炎患者在发病后的1～10年内发生哮喘。尘螨(屋尘螨和粉尘螨)是哮喘和变应性鼻炎最常见的变应原。结论调查结论支持变应性鼻炎和哮喘是一种疾病的观点,其诊断和防治也应结合起来进行考虑。

Objective To find supporting evidences for the concept of allergic rhinitis and asthma as one disease based on a clinical epidemiological survey to seek the association of these two conditions. Methods Surveyed in this study were 3 210 cases with asthma, among whom the association of allergic rhinitis with asthma was carefully analyzed, with allergens determined by intra-dermal test among 1 960 Patients and by skin-prick test among 1 250 ones. Results Among the cases with asthma, 2 684 （83.61%） complicated with allergic rhinitis, with allergic rhinitis occurred Precedingly or simultaneously with the attack of asthma among 2 402 cases （74.80%） in the latter sub-population of cases. Most Patients suffering from allergic rhinitis might develop into asthma at last within 1 to 10 years. The most commonly seen allergen determined in this group of cases was that of dust mites, especially that of Dermatophagoides, Pterongssinus and Dermatophagoides farinae. Conclusions The results of this survey support the concept of allergic rhinitis and asthma as one disease, and this concept should be integrated into the clinical Practice for diagnosis, treatment and Prevention of these two conditions.