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尾加压素Ⅱ基因多态与脑卒中

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摘要 尾加压素Ⅱ(urotensin Ⅱ,UⅡ)是一种新近发现的神经肽及血管活性肽,最新证据表明,UⅡ与脑血管病发生、发展的多种主要危险因素如动脉粥样硬化、高血压、糖尿病、高血脂等相关。UⅡ基因S89N(即3836C/T)位点的多态亦被发现与原发性高血压、2型糖尿病的发生有关,然而UⅡ基因多态与脑卒中遗传易患性的研究国内外未见报道。我们对UⅡ基因S89N位点的单核苷酸多态与脑卒中的关系进行分析,为脑血管病防治提供思路。
出处 《中华神经科杂志》 CAS CSCD 北大核心 2008年第3期185-186,共2页 Chinese Journal of Neurology
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参考文献8

  • 1Coulouarn Y, Lihrmann I, Jegou S, et al. Cloning of the cDNA encoding the U Ⅱ precursor in frog and human reveals intense expression of the urotensin Ⅱ gene in motoneurons of the spinal cord. Proc Nail Acad Sci USA, 1998,95:15803-15808.
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