人白细胞抗原DR在特发性肺纤维化中的表达

Expression of human leukocyte antigen-DR in idiopathic pulmonary fibrosis

目的探讨特发性肺纤维化（IPF）的免疫学发病机制。方法采用免疫组织化学法检测10例特发性肺纤维化患者（IPF组）和5例肺癌患者癌旁正常肺组织（对照组）中人白细胞抗原（HLA）DR的表达情况。结果IPF组肺泡上皮及细支气管上皮细胞HLA—DR阳性累积积分为27分，对照组累积积分为2分，IPF肺组织肺泡上皮及细支气管上皮HLA—DR表达上调，与对照组比较差异有统计学意义（Z=-3．002，P=0．001）。结论特发性肺纤维化肺泡上皮及细支气管上皮HLA—DR表达上调，推测其可能在上皮损伤、肺组织的异常修复即肺纤维化过程中起重要作用。

Objective To study the expression of human leukocyte antigen （HLA） -DR in the lungs of the patients with idiopathic pulmonary fibrosis （IPF）, and to explore the possible autoimmunity mechanisms of lung fibrosis. Methods Methods Immunohistochemistry （ SP method） was used to detect the expression of HLA-DR in the lung specimens from 10 IPF patients and in 5 specimens of normal lung tissue immediately adjacent to lung carcinomas as controls. Results HLA-DR antigens were expressed in the hyperplastic bronchio-alveolar epithelial cells in IPF, but not in the epithelial cells of the normal control lung tissues. The accumulated positive scores of HLA-DR of the IPF group was 27, significantly higher than that of the control group （2, Z = - 3. 002, P = 0. 001 ）. Conclusions Inappropriate HLA-DR expression is present in the bronchio -alveolar epithelium in IPF. Immune dysfunction may play an important role in the development of IPF.