宫颈神经内分泌癌临床与病理分析

Clinicopathologic Analysis of Neuroendocrine Cervical Carcinoma

[目的]探讨宫颈神经内分泌癌(NECC)的临床病理特征及治疗方式。[方法]回顾性分析9例宫颈神经内分泌癌患者的临床期别、症状,病理特点(包括肿瘤直径大小、病理类型、间质浸润、脉管转移、淋巴结转移、神经内分泌标记物),以及治疗方式。电话随访预后情况。[结果]9例患者平均年龄38.1岁,Ⅰb期4例,Ⅱa期5例,均无全身内分泌症状。8/9例均至少有2种神经内分泌标记阳性。9例患者中1例失访,余8例患者均接受综合治疗,目前均存活,无复发及远处转移。[结论]神经内分泌标记有助于该病的诊断;综合治疗有利于提高患者的生存率,延长复发时间。

[Purpose] To investigate the clinicophathologic characteristics and treatment of neuroendocrine cervical carcinoma （NECC）. [Methods] Clinic stage, manifestation, pathological characters and treatment of 9 cases with NECC were analyzed retrospectively. The pathological characters included tumor size, pathological type, stroma invasion, vessel and lymph node involvement and neuroendocrine markers. The patients were followed up with telephone. [Results] Average age of the 9 cases （with stage Ⅰ b in 4 cases and stage Ⅱ a in 5 cases） was 38.1 years old. No patient had systematic endocrine disfunction. Patients（8/9） in overwhelming majority had at least 2 neuroendocrine markers positive. One in the 9 cases lost follow-up. Eight patients undergoing multi-modality therapy were alive so far with no recurrence and distant metastasis. [Conclusion] Neuroendocrine markers are useful for the diagnosis of NECC. Multi-modality therapy is valuable for improving survival and prolonging time to relapse.