鼻咽癌患者治疗后质量调整生命年的研究

Research of Quality-Adjusted Life Years in Nasopharyngeal Carcinoma Patients after Treatment

目的计算鼻咽癌患者治疗后的质量调整生命年,探讨影响质量调整生命年的因素。方法对复查的304例鼻咽癌患者采用华盛顿大学生命质量量表简体中文第4版进行调查,以生命量表得分为权重,计算质量调整生命年。运用相关分析、t检验和多元线性回归评价QALY的影响因素。结果平均权重是0.70。偏相关分析说明随访时间与QALY呈负相关,与生命质量无相关关系。结合QALY的单因素和多因素分析,提示:生命质量得分越高、N分期越早,QALY越高,而年龄、是否复发、随访时间与之呈负相关。结论QALY结合考虑生命质量和生存时间的损失对鼻咽癌患者的影响,是综合评价患者疾病负担的有效方法。

Objective To evaluate the quality-adjusted life year（QALY） and its influencing factors in nasopharyngeal carcinoma （NPC） patients after treatment. Methods 304 patients with nasopharyngeal carcinoma treated in our hospital were evaluated using simplified Chinese edition of Washington University-QOL （UW-QOL） Version 4. QALY were calculated by using UW-QOL score as the weight. Correlation analysis ,t test and multiple linear regression were used to evaluate the influencing factors. Results The average weight was 0.70. Partial correlative analysis demonstrated that follow-up time was negatively correlated with QALY,but it was not correlated with WU-QOL. Univariate and multivariate analysis showed that QALY was related to the WU-QOL score and N stage, whereas age, recurrence and follow-up time were negative correlated with it. Conclusion QALY could serve as an effective way to evaluate burden of disease in NPC patients by considering both the loss of QOL score and survival time.