血清C-反应蛋白在冠心病患者中的变化及其意义

The Changes of Serum C-reactive Protein Level in Patients with Coronary Artery Disease and Its Clinical Significance

目的:探讨冠心病(CAD)患者血清C-反应蛋白(CRP)的变化及其临床意义。方法:运用全自动生化分析仪检测97例CAD患者和28例对照组人群的血清CRP,将CAD患者进一步分为急性冠脉综合征(ACS)和非急性冠脉综合征(N-ACS)两组。另外,将97例CAD患者分为1支病变组、2支病变组和3支病变组。所有研究对象均行选择性冠状动脉造影检查。结果:(1)与对照组比较,CAD患者血清CRP显著升高(P<0.05);(2)与对照组比较,ACS组和N-ACS组患者血清CRP均显著升高(P<0.05);与N-ACS组比较,ACS组患者血清CRP亦显著升高(P<0.05);(3)与对照组比较,1支病变组、2支病变组和3支病变组患者血清CRP均显著升高(P<0.05);与1支病变组比较,2支病变组和3支病变组患者血清CRP亦显著升高(P<0.05);与2支病变组比较,3支病变组患者血清CRP亦显著升高(P<0.05)。结论:(1)CRP可能与CAD有关;(2)CRP异常升高可能反映冠状动脉斑块的不稳定和CAD的严重程度。

Objective： To study the changes of serum C-reactive protein （CRP） level in patients with coronary artery disease （CAD） and its clinical significance. Methods： CRP levels of 97 patients with CAD diagnosed by using coronary angiography, and 28 people without the disease （control group） were measured with automatic biochemical analysator. All the CAD patients were divided into subgroups of acute coronary syndrome （ACS） and non-acute coronary syndrome （ NACS）, and into subgroups of one diseased vessel （ subgroup 1 ）, two diseased vessels （ subgroup 2）, and three diseased vessels （subgroup 3）. The data were analyzed. Results： （1） CRP in patients with CAD was significantly higher than that of control group （P 〈0. 05） ; （2） CRP in patients with ACS and without ACS was significantly higher than that of control group （P 〈 0. 05 ）, also, CRP in patients with ACS was significantly higher that of patients in subgroup NACS, （P 〈 0. 05 ） ; （3） CRP in patients of subgroup 1,2, and 3 was significantly higher than that of people of control group （P 〈 0. 05 ） ; CRP in patients of subgroups 2 and 3 was higher than that of subgroup 1 （P 〈 0. 05 ）, and that of subgroup 3 was higher than that of subgroup 2 （P 〈 0. 05 ）. Conclusions： （ 1 ） CRP may be correlated with CAD ; （2） The increase of CRP level may reflect the instability of coronary artery plaque and the severity of CAD.