胸腺肽、干扰素辅助治疗毛细支气管炎

The Auxiliary treatment for bronchiolitis with thymic peptide and interferon.

目的探讨胸腺肽、干扰素辅助治疗毛细支气管炎的临床疗效。方法对毛细支气管炎患儿223例,随机分为胸腺肽治疗组50例,干扰素治疗组67例,胸腺肽联合干扰素治疗组50例及对照组56例。对照组给予止咳平喘,普米克令舒加博利康尼雾化,退热,吸痰吸氧等综合治疗,治疗组在对照组基础上分别加用胸腺肽50mg/d,静脉滴注,疗程5d,-α2b干扰素50-100万U/d,肌肉注射,疗程5d,及联用胸腺肽和-α2b干扰素治疗。观察各组患儿主要临床症状体征恢复及住院时间。结果各治疗组的发热、喘憋、咳嗽、肺部干、湿音消失时间及住院时间均短于对照组（P〈0.05）,胸腺肽联合干扰素治疗组疗效最佳（P〈0.05）,而干扰素治疗组疗效又优于胸腺肽组。结论应用胸腺肽、干扰素辅助治疗毛细支气管炎,疗效显著,能缩短病程,尤其两药联用疗效更佳,值得临床推广。

Objective To explore the effect of thymie peptide, interferon on bronehiolitis. Methods 223 eases with bronehiolitis were randomly divided into four groups：50 eases in the thymie peptide treatment group,67 eases in the interferon treatment group,50 eases in the tymie pepide combined with interferon treatment group and 56 eases in the control group. The control group was treated with a comprehensive therapy of relieving cough and asthma, nebulization, defervescence, Aspirating sputum, oxygen uptaking, and the treatment group with thymie peptide（50mg/d iv gtt,5days） ,α-2b interferon（50 - 100 万U/d,im,5days） ,the two drug combination respectively in addition. The different recovery time of clinic symptom and physical signs was observed among the patients of four groups. Results The time need for the disappearance of fever, gasp,coughing,rales of chest and the hospitalization days of treatment group were significantly shorter than that of the control respectively（ P 〈 0.05）. That of drug combination group is the best,and interferon treatment group is better than that of thymie peptide group. Conclusion Tymie peptide,interferon is effective in treating bronehiolitis,and thymie peptide combined with interferon treatment is the best. It＇s worthy of extensive application for clinic work.