银杏叶注射液对急性冠状动脉综合征患者血浆神经肽Y、神经降压素水平的影响

The Infection of Ginkgo Biloba Injection on the Plasma Neurotens in and Neuropeptide Y in Patients with Acute Coronary Syndrome

目的观察银杏叶注射液对急性冠状动脉综合征(ACS)患者血浆神经肽Y(NPY)及神经降压素(NT)水平的影响。方法用放射免疫分析法测定73例ACS患者血浆NPY、NT的水平,并以60例健康者作对照,观察ACS患者常规治疗及在其基础上加用银杏叶注射液静注后NPY、NT的水平变化。结果ACS患者血浆NPY和NT水平均明显高于对照组(P<0.05),常规治疗及加用银杏叶注射液治疗后NPY水平均有明显下降,且银杏叶注射液组较常规治疗组下降更显著(P<0.05)。结论银杏叶注射液可明显降低ACS患者血浆NPY、NT水平,对改善患者心肌缺血及心功能有重要作用。

Objective To observe the infection of Ginkgo Biloba Injection （GBI） on the plasma Neuropeptide Y （NPY） and Neurotensin （NT） in patients with Acute Coronary Syndrome （ACS）.Methods Levels of plasma NPY and NT were measured by radioimmunoassay （RIA） in serventy-three ACS patients and sixty normal subjects. We observe the differences between treatment with and without GBI administered intravenously and the level changes of NPY and NT after treatment with GBI. Results Plasma NPY and NT levels in ACS patients are significantly higher than normal subjects （ P 〈 0.05） ;Both NPY and NT are decreased after normal treatment and treatment with GBI,and it is more evident in treatment with GBI（ P 〈 0.05）. Conclusion Both NPYf NT participate in the pathophysical progression of ACS, GBI can clearly lower levels of NPY and NT. GBI antagonizes the effects of NPY on constricting vessels and it plays an important role in improving myocardial ischemia and cardiact function of the patients.