沙培林和平阳霉素注射治疗婴儿血管瘤临床对比研究

Comparison between intralesiona injeted bleomycin A5 and group A streptococcus Preparation for the treatment of hemangioma in infant

目的探讨平阳霉素、沙培林用于血管瘤注射治疗的疗效。方法将1月到1岁的120个小儿增生期血管瘤随机分为瘤体内注射平阳霉素组和注射沙培林组各60例,观察治疗效果和并发症。结果平阳霉素组的有效和显效率明显优于沙培林组(P<0.05),两组的并发症除发热(P<0.005)外,其余并发症均无统计学意义(P>0.05)。结论瘤体内注射沙培林和平阳霉素治疗血管瘤均是有效,但以平阳霉素的疗效较佳。

Objective To investigate the therapeutic efficacy of bleomycin A5 and group A streptococcus prepamtion for the treatment of hemangioma in infant. Method 120 infants between one month and one year old with cutaneous proliferating hemangioma were randomly divided into two groups. 60 children were treated with intra-lesion bleomycin A5 hydrochloride for injection （0.8 rag/ ml） （group A）. Meanwhile another 60 children were treated with intra-lesiona injected group A streptococcus preparation （0.1 - 0.2 KE/ml）（group B）. The treatment outcome and complications were observed between two groups. Results The effective rate and cure rate in the group A were significantly higher than that group B（P 〈 0.005）. The side effects （except fever） were no obvious difference. Conclusion Intra-lession injected Bleomycin A5 and Group A streptococcus preparation were effective, but the former is better than that the letter.