摘要
蛋白酶活化受体（protease activated receptors，PARs）家族是血栓形成中的重要G蛋白耦联受体家族．是凝血酶的主要受体。PARs有4种亚型（PAR1～4）。PAR1是PARs家族的主要成员，是最早发现的PARs分子，研究最为深入。PAR1在血栓形成、炎症反应、血管活性、免疫系统功能、血管增生性疾病等过程中发挥重要作用。
出处
《实用医学杂志》
CAS
2008年第4期499-501,共3页
The Journal of Practical Medicine
参考文献24
-
1Damiano B P, Derian C K, Maryanoff B E, et al. RWJ 58259: a selective antagonist of protease activated receptor-R 1 [J]. Cardiovasc Drug Rev, 2003,21(4) : 313-326.
-
2EvenRam S C, Grisaru-Granovsky S, Pruss D, et al. The pattern of expression of protease activated receptors (PARs) during early trophoblast development [ J ]. J Pathol, 2003,200( 1 ) : 47-52.
-
3Boire A, Covic L, Agarwal A, et al. PAR1 is a matrix metalloprotease 1 receptor that promotes invasion and tumorigenesis of breast cancer cells [J]. Cell, 2005,120(3):303-313.
-
4Liu J, Schuff-Wemer P, Steiner M. Double transfection improves small interfering RNA induced thrombin receptor (PAR1) gene silencing in DU 145 prostate cancer cells [J]. FEBS Lett, 2004, 577(1-2) : 175-180.
-
5Martin C B, Mahon G M, Klinger M B, et al. The thrombin receptor, PAR1, causes transformation by activation of Rho mediated signaling pathways [J]. Oncogene, 2001,20(16) : 1953- 1963.
-
6Turcotte S, Desrosiers R R, Brand G R, et al. yon Hippel Lindau tumor suppressor protein stimulation by thrombin involves RhoA activation [J]. Int J Cancer, 2004,112(5):777-786.
-
7Feistritzer C, Riewald M. Endothelial barrier protection by activated protein C through PAR1 dependent sphingosine-1- phosphate receptor 1 cross activation [J ]. Blood, 2005,105 (8) : 3178-3184.
-
8Zain J, Huang Y Q, Feng X, et al. Concentration dependent dual effect of thrombin on impaired growth/apoptosis or mitogenesis in tumor cells [J]. Blood, 2000,95(10) :3133-3138.
-
9Huang Y Q, Li J J, Hu L, et al. Thrombin induces increased expression and secretion of VEGF from human FS4 fibroblasts,DU145 prostate cells and CHRF megakaryocytes [J]. Thromb Haemost, 2001,86(4) : 1094-1098.
-
10Yin Y J i Salah Z, Maoz M, et al. Oncogenic transformation induces tumor angiogenesis: a role for PAR1 activation [J]. FASEB J, 2003,17(2) : 163-174.
同被引文献23
-
1CZYZ J. The stage-specific function of gap junctions during tumourigenesis [ J ] . Cell Mol Biol Lett, 2008, 13(1): 92- 102.
-
2KAILDOUZ M, BATIST G. Gap junctions and connexins as therapeutic targets in cancer [ J ] . Expert Opin Ther Targets, 2010, 14(7): 681-692.
-
3VILLARES G J, DOBROFF A S, WANG H, et al. Overexpression of protease-activated receptor-I contributes to melanoma metastasis via regulation of connexin 43 [ J ] . Cancer Res, 2009, 69(16): 6730-6737.
-
4ZHU Q, LUO J, WANG T, et al. The activation of protease- activated receptor 1 mediates proliferation and invasion of nasopharyngeal carcinoma cells [ J ] . Oncol Rep, 2012, 28(1): 255-261.
-
5AHN H S, FOSTER C, BOYKOW G, et al. Inhibition of cellular action of thrombin by N3-cyclopropyl-7-{ [ 4- (1-methylethyl)phenyl ] methyl] -7H-pyrrolo [ 3, 2-f ] quinazoline-1, 3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist [ J ] . Bioehem Pharmacol, 2000, 60: 1425-1434.
-
6HILLS C E, BLAND R, BENNETT J, et al. TGF-betal mediates glucose-evoked up-regulation of connexin-43 cell- to-cell communication in HCD-eells [ J ] . Cell Physiol Biochem, 2009, 24(3-4): 177-186.
-
7BATES D C, SIN W C, AFTAB Q, et al. Connexin43 enhances glioma invasion by a mechanism involving the earboxy terminus [ J ] .Glia, 2007, 55(15): 1554-1564.
-
8KANCZUGA-KODA L, SULKOWSKI S, LENCZEWSKI A, et al. Increased expression of connexins 26 and 43 in lymph node metastases of breast cancer [ J ] . J Chn Pathol, 2006, 59(4): 429-433.
-
9LIN J H, TAKANO T, COTRINA M L, et al. Connexin 43 enhances the adhesivity and mediates the invasion of malignant glioma cells [ J ] . J Neurosci, 2002, 22(11): 4302- 4311.
-
10COTR1NA M L, LIN J H, NEDERGAARD M. Adhesive properties of connexin hemichannels [ J ] . Glia, 2008, 56: 1791-1798.
-
1汪宏梅.结肠癌组织中蛋白酶活化受体-1的表达及意义[J].国际检验医学杂志,2013,34(24):3320-3321. 被引量：2
-
2徐晶,金志军,谢康云,张莺.蛋白酶活化受体-1在宫颈癌组织中的表达及意义[J].上海医学,2008,31(8):546-548. 被引量：1
-
3楚罗湘,覃月秋,莫昌干,周素娴,杨帆,梁志山.急性冠脉综合征患者血小板蛋白酶活化受体-1的表达及普伐他汀体外干预的影响[J].实用医学杂志,2015,31(24):4018-4021. 被引量：6
-
4顾小红,张云东,刘迎春.PAR_S调控大鼠HSC合成和分泌胶原蛋白的作用[J].重庆医科大学学报,2010,35(7):985-988. 被引量：4
-
5马文静,何韶衡,周艳春,陈玉珍,黄阗,方泽漫,陈霖霏.蛋白酶活化受体-1单克隆抗体的制备与鉴定[J].西安交通大学学报（医学版）,2007,28(4):458-461.
-
6林伟基,刘彩云.变态反应性疾病的实验室数据与病例分析（一）[J].中国检验医学与临床,2000,1(2):58-58.
-
7张艳,丁家望.蛋白酶活化受体2与心肌细胞凋亡[J].中国微循环,2009,13(6):592-594.
-
8顾小红,房殿春,陈东风.PARs对肝纤维化大鼠HSC活化和增殖的调控作用[J].胃肠病学和肝病学杂志,2007,16(4):357-360. 被引量：3
-
9蔡颖,冯健,李家富.G蛋白耦联胆汁酸受体5和代谢性疾病[J].中华高血压杂志,2016,24(6):527-530. 被引量：1
-
10严蓉,古存,朱珊珊,曾因明.B型γ-氨基丁酸受体及其应答机制[J].国外医学（麻醉学与复苏分册）,2005,26(1):33-35. 被引量：7
