糖尿病高血压和糖尿病肾病患者血清MMP-2及TIMP-1的表达及意义

Clinical Significence and Serum MMP-2 and TIMP-1 with Diabetic Hypertention and Diabetic Nephropathy

为了探讨MMP-2、TIMP-1在DMEH和DN发病中的意义,随机收集T2DM患者146例,其中SDM57例,DMEH38例,DN51例,健康对照38例。用ELISA法测定MMP-2、TIMP-1的含量。结果显示,DM患者尤其是DMEH和DN患者血清MMP-2明显低于健康对照组,P均<0.01,且随病情发展呈逐渐降低趋势。而血清TIMP-1随病情的发展则呈现明显的上升趋势,SDM、DMEH组和DN组与健康对照组比较,分别为P<0.05,P<0.01和P<0.01。因此,MMP-2和TIMP-1可能参与了DMEH和DN的发生发展过程,定期检测DM患者血清MMP-2和TIMP-1的含量变化有助于DM并发症的早期诊断和疗效观察。

To find out the regularity of the changing of serum matrix metalloproteinase-2（MMP-2） and tissue inhibitor of metalloproteinase -1（TIMP-1） in the patients with diabetes type 2. To discuss the roles played by MMP-2 and TIMP-1 in the patients with high blood pressure and kidney harm related to diabetes.Randomly collected 146 cases of patients with diabetes type 2, in which 57 cases were the diabetic patients without other syndromes,38 cases were the diabetic patients with hypertension,51 cases were the diabetic patients with nephropathy. And 38 cases were the healthy ones as contrast. The levels of serum MMP-2 and TIMP-1 were measured by ELISA.The content of MMP-2 in the diabetic patients was significantly lower than that in the healthy ones, and MMP-2 in the diabetic patients with high blood pressure and nephropathy was even much lower, P〈0.01,P〈0.01;and was getting lower with the development of the disease.Meanwhile, TIMP-1 was getting higher with the development of the disease, P values were respectively P〈0.05,P〈0.01 and P〈0.01 compared with the contrast to the groups of the cases without other syndromes, with high blood pressure and with nephropathy.MMP-2 and TIMP-1 were likely to be the participants in the process of occurrence and development of diabetic high blood pressure and kidney nephropathy. Measuring the content of MMP-2 and TIMP-1 could properly provide a new reference to the early diagnoses and treatments of the diabetes and its syndrome.