广东石豆兰中的噁庚英和联苄类化合物

Oxepine and Bibenzyl Compounds from Bulbophyllum kwangtungense

从兰科植物广东石豆兰(Bulbophyllum kwangtungense Schlecht.)的乙酸乙酯部分分离得到了2个新的茋类化合物5-(2,3-二甲氧苯乙基)-6-甲基苯并[d][1,3]二氧戊环(1)和10,11-二氢-2,7-二甲氧基-3,4-亚甲二氧基二苯并[b,f]噁庚英(2).药理活性实验结果证明,化合物2对体外培养的Hela细胞有较强的抑制作用.

Phytohemical investigation of the EtOAc extract of leaves and stems of Bulbophyllum kwangtungense Schlecht. , belonging to the orchid family was carried out. Two new stilbenods were isolated by repeat column chromatography and characterized ： one is bibenzyl compound, 5- （ 2,3-dimethoxyphenethyl ） -6-methylbenzo [ d] [ 1,3 ] dioxole （ 1 ）, and the other dibenz [ b, f] oxepine, 10, 11-dihydro-2,7-dimethoxy-3,4-methylenedioxy dibenzo[ b, f] oxepine（2）. Their structures were established on the basis of analyses of spectroscopic evidence, particularly by two-dimensional NMR spectroscopic analysis. Bibenzyl compound with a methyl group in the benzene ring is rarely found from natural sources. Natural oxepines are very rare, and most of them were reported to have good anti-tumor activities. In addition, anti-tumor activities of the new compounds were also evaluated. Among the compounds isolated, compound 2 showed anti-tumor activities with IC50 value of 47. 2 μg/mL in vitro against Cultures of Hela cells.