摘要
Biodegradable α-hydroxyl polyesters,such as poly(lactic acid)(PLA)and poly(lactic-co-glycolic acid)(PLGA)were investigated as scaffolds for tissue engineering.However,polymeric materials on the basis of lactide are limited in blood vessel engineering due to their poor hydrophilicity and low affinity for the cells.In this study,the functional polylactide with pendant carboxyl(PLMACA)was synthesized,which was expected to improve the blood compatibility and cell adhesion of polyester based on PLA.The structure and composition of PLMACA were confirmed via {}1H NMR spectrum and the compatibilities for blood and cell were stu-{died.} The results show that the PLMACA is hopeful to be used as blood vessel substitute with good HUVEC adhesion and anti-platelet adhesion.
Biodegradable α-hydroxyl polyesters, such as poly （lactic acid） （PLA） and poly （lactic-co-glycolic acid） （PLGA） were investigated as scaffolds for tissue engineering. However, polymeric materials on the basis of lactide are limited in blood vessel engineering due to their poor hydrophilicity and low affinity for the cells. In this study, the functional polylactide with pendant carboxyl（PLMACA） was synthesized, which was expected to improve the blood compatibility and cell adhesion of polyester based on PLA. The structure and composition of PLMACA were confirmed via ^1H NMR spectrum and the compatibilities for blood and cell were studied. The results show that the PLMACA is hopeful to be used as blood vessel substitute with good HUVEC adhesion and anti-platelet adhesion.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2008年第2期433-435,共3页
Chemical Journal of Chinese Universities
基金
国家“九七三”计划(批准号:2005CB623904)资助
关键词
聚乳酸
血液相容性
内皮细胞
粘附
Polylactide
Blood compatibility
Human umbilical vein endothelial cell（HUVEC）
Adhesion
