摘要
目的:探讨流式细胞术检测宫颈细胞DNA倍体在宫颈病变中的应用价值。方法:对290例患者的液基细胞学检测后剩余细胞行流式细胞术DNA倍体分析,其中非典型鳞状上皮增生(ASCUS)120例、低度宫颈上皮内瘤变(LSIL)90例、高度宫颈上皮内瘤变(HSIL)60例、鳞状上皮癌(SCC)20例。结果:①异倍体在ASCUS组、LSIL组、HSIL组、SCC组中检出率分别为3.3%、31.1%、85.0%、96.7%。②LSIL、HSIL、SCC 3组的异倍体率与ASCUS组比较有显著性差异(P<0.05);HSIL、SCC 2组的异倍体率与LSIL组比较差异显著(P<0.05);HSIL、SCC 2组的异倍体率之间无统计学差异(P>0.05)。结论:DNA倍体分析可以作为宫颈病变早期的筛查手段。
Objective： To explore the value of DNA ploid analysis by flow eytometry in cervical lesions. Methods： Flow eytometry （FCM） was used to detect the cervical cells of 290 patients [ atypical squamous cells of undetermined significance （ASCUS） 120, low -grade squamous intraepithelial lesion （LSIL） 90, high- grade squamous intraepithelial lesion （HSIL） 60, squamous cell cancer （SCC） 20] . Results： ①The rate of heteroploid was 3.3% in ASCUS group, 31.1% in LSIL group, 85% in HSIL group, 96. 7% in SCC group. ②Heteroploid level of LSIL, HSIL, SCC group differed from that of ASCUS group （P 〈0. 05 ） . Heteroploid level of HSIL, SCC group were different from that of LSIL group （ P 〈 0.05 ）, while no significant difference was found between HSIL group and SCC group （ P 〉 0. 05 ）. Conclusion： DNA content analysis is helpful in early diagnosis of the cervical lesions.
出处
《中国妇幼保健》
CAS
北大核心
2008年第1期85-87,共3页
Maternal and Child Health Care of China
关键词
宫颈细胞
流式细胞术
异倍体
DNA倍体
Cervical cells
Flow eytometry
Heteroploid
DNA content analysis
