C-反应蛋白在多囊卵巢综合征中的变化及意义

The changes of C-reactive protein in polycystic ovarian syndrome and its significance

目的:探讨多囊卵巢综合征(PCOS)患者血清中C-反应蛋白(CRP)的变化及与胰岛素抵抗的关系。方法:将46例PCOS患者按体重指数(BMI)分为非肥胖PCOS组(18例)和肥胖PCOS组(28例),27例正常妇女分为非肥胖对照组(11例)和肥胖对照组(16例)。测定血清卵泡刺激素(FSH)、黄体生成素(LH)、泌乳素(PRL)、雌二醇(E2)、睾酮(T)、空腹血糖(FPG)、空腹胰岛素(FINS)、CRP浓度。结果:PCOS组LH、LH/FSH、T、FINS显著高于对照组,胰岛素敏感指数(ISI)显著低于对照组,两组CRP水平无显著差异。肥胖PCOS组和肥胖对照组血清CRP水平均显著高于各自的非肥胖组。血清CRP水平与BMI、FINS呈正相关,与ISI呈负相关。结论:PCOS患者不存在慢性亚临床炎症,心血管病风险仅限于合并肥胖或胰岛素抵抗的PCOS患者。

Objective： To investigate the concentration of CRP in polycystic ovary syndrome （PCOS） and its relation to insulin resistance. Methods： 46 patients with PCOS （non -obese PCOS group, 18; obese PCOS group, 28） and 27 healthy women （non -obese control group, 11 ; obesecontrol group, 16） were chosen for study. FSH, LH, PRL, E2, T, fasting insulin （FINS）, fasting plasma glucose （FPG）, CRP level were measured. Results： LH, LH/FSH, T, FINS in patients were significant higher than those in control groups; insulin sensitive index （ISI） was reduced in PCOS compared with control. No differences were observed between both groups in CPR. CRP levels were significant higher in obese PCOS and obese control groups than that in no - obese groups. CRP was positively related with BMI, FINS and negtively related with ISI. Conclusion： There is no low grade chronic inflammation in patients with PCOS. In PCOS, the CVD risk may be confined to those with obesity or/and insulin resistance rather than affecting all women with syndrome.