血管内皮生长因子与卵巢癌细胞凋亡的关系

Expression of vascular endothelial growth factor (VEGF) in epithelial ovarian carcinoma and its relationship with the apoptosis

目的:探讨血管内皮生长因子(VEGF)在卵巢癌中的表达及其与细胞凋亡的关系。方法:分别采用免疫组织化学SP法和TUNEL检测VEGF在45例卵巢癌中的表达及细胞凋亡情况。结果:45例卵巢癌中VEGF阳性表达率为86.7%(39/45)。卵巢癌组织中60%(27/45)细胞凋亡为阳性,40%(18/45)细胞凋亡为阴性。卵巢癌细胞凋亡阴性组中VEGF强阳性表达率88.9%(16/18)高于细胞凋亡阳性组40.7%(11/27),P=0.039。结论:VEGF抑制肿瘤细胞凋亡,促进肿瘤生长、局部侵袭及远处转移。

Objective： To determine the expression of vascular endothelial growth factor （VEGF） in ovarian cancer and its relationship with the apoptosis. Methods： The expression of VEGF was evaluated by SP immunohistochemical method, the apoptosis was detected by TUNEL in 45 cases with epithelial ovarian cancer. Results： Positive immunostaining for VEGF was 86. 7% （39/45）. The negative apoptosis group of ovarian cancer had higher VEGF expression than positive group （ P = 0. 039 ） . Condclusion： There is a close relationship between VEGF expression and tumor progression in epithelial ovarian patients. The growth, local invasion and metastasis of tumor can be promoted by the VEGF, while the apoptosis is inhibited.