胞液型磷脂酶A_2在婴幼儿支气管肺炎中的变化及意义

Changes of cytochyma phospholipase in bronchopneumonia in infants

目的:探讨婴幼儿支气管肺炎血清胞液型磷脂酶A2(cPLA2)的水平变化及意义。方法:运用酶联免疫吸附法(ELISA)测定50例婴幼儿支气管肺炎的cPLA2的水平变化,同时,以同期在门诊健康体检婴幼儿作为对照。结果:肺炎组cPLA2水平明显高于健康对照组,有统计学意义(P<0.01)。结论:cPLA2在婴幼儿肺炎时明显增高,说明了cPLA2参与了肺炎的病理生理过程,如能早期应用cPLA2抑制剂,可对肺炎的转归有一定干预作用。

[Abstract] Objective： To explore the changes of cytochyma phospholipase in bronchopneumonia in infant. Methods： ELISA was used to determine the level of cPLA2 enzymatic activity with bronchopneumonia in infant and out -patient healthy infants. Results： The level of bronchopneumonia groups was significantly higher than that of healthy infants （P 〈 0. 01 ） . Conclusion： Cytochyma phospholipase is higher during the period of bronchopneumonia that is cPLA2 take part in the course of bronchopneumonia pathophysiology. The early administeration of inhibitor of cytochyma phospholipase is benefit to the turnover of bronchopneumonia.