胎儿生长受限孕妇血浆活化蛋白c抵抗与抗心磷脂抗体检测结果分析

Relationship between the activated protein C resistance and anticardiolipin antibodies in patients with fetal growth restriction

目的:研究活化蛋白c抵抗(APCR)、抗心磷脂抗体(ACA)与胎儿生长受限(FGR)的相关性,并进一步探讨FGR患者APCR与ACA的关系。方法:采用APTT±APC法检测20例原因不明FGR患者(实验组)、35例正常待产妇(对照组)的APCsr;Elisa方法检测ACA-IgG、IgM滴度水平。结果:①实验组APCR阳性率60.0%,明显高于对照组(31.4%),P(0.05;②实验组ACA阳性率20.0%,对照组2.9%,差异有显著性;③APCR阳性组ACA阳性3例,阴性组ACA阳性2例,无显著差异。结论:APCR和ACA均是FGR的危险因素,但获得性APCR的发生并非ACA抑制蛋白c通路导致凝血异常及导致FGR形成的唯一通路。

Objective： To examine the activated protein C sensitive ratio and the presence of anticardiolipin antibodies in pregnancies complicating with fetal growth restriction to explore the mechanism of fetal growth restriction. Methods： An activated partial thromboplastin time （APTT） - based assay for APCsr and ELISA for ACA of 20 pregnancies with idiophathic fetal growth restriction and 35 normal pregnancies. Results： The incidence of APCR and ACA in FGR group was higher than normal pregnant women,, and the difference was significant （ P 〈 0. 05 ） . Conclusion： The presence of either activated protein C resistance or ACA may contribute to risk of fetal growth restriction. There is not a significant interaction between APCR and ACA in pregnancies with fetal growth restriction.