新生儿静脉血补体检测及临床意义

Detection and analysis of complement in neonatal venous blood

目的:分析新生儿静脉血补体(C3、C4)的特点,以进一步探讨其与新生儿疾病的关系。方法:采集新生儿静脉血采用美国贝克曼库尔特有限公司的IMMAGE双光径免疫浊度分析仪(免疫比浊法)测定补体(C3、C4)含量,并对其进行分析,根据不同胎龄、体重、分娩方式、性别等进行比较,总结其特点。结果:227例新生儿静脉血C3:(0.47±0.14)g/L,C4:(95.13±39.17)mg/dl。静脉血C3、C4在不同胎龄的新生儿有统计学意义(P<0.01),C3、C4在不同体重(≤1500g组和>2500g组)新生儿有统计学意义(P<0.05);男女新生儿静脉血C3、C4没有统计学意义(P>0.05)。结论:胎龄小,补体(C3、C4)低;体重低,C3、C4低;不同性别及不同分娩方式新生儿C3、C4无差别。对于低补体病例,应加以重视,及时输血浆。

Objective： To analyze the characteristics of complement in neonatal venous blood, in order to discuss the relationship between diseases of newborn and complement. Methods： Collected neonatal venous blood and determined the content of complement in neon-atal venous blood by immune nephelometry. Carried though retrospective analysis and processed comparisons according to the differential gestational age, body weight, delivery mode and sex. Results： C3 in all 227 cases were （0.47±0.14） g/L, C4 in all 227 cases were （95.13±39.17） mg/dl. The content of C3 and C4 in different gestational age newborns had statistical significance （P〈0.01）. Compared with the infants whose body weight blow 1500 g, the contents of C3 and C4 in the infants whose body weight were more than 1500 g appeared significant variation （P〈0.05） ; The content of C3 and C4 in male and female newborns had no statistical significance （P〉0.05）.Conclusion： The smaller gestational age , the lower content of C3 and C4 ; The lower body weight , the lower content of C3 and C4 ; The content of C3 and C 4 in newborns with different gender or different delivery way has no difference. It is necessary for the patients whose contents of complement are lower to be given blood plasma.