肝胆显像分析大黄虫丸对肝细胞功能的影响

Evaluation of hepatocellular function influenced by Chinese drug Dahuang Zhechong pill

目的:分析大黄虫丸对肝炎肝硬化患者的肝细胞功能的影响。方法:对37例肝炎肝硬化患者及12例正常对照者进行肝胆动态显像定量分析肝细胞功能,其中19例患者给予大黄虫丸治疗后6月复查了肝胆显像,比较治疗前后肝细胞摄取和排泄功能变化,并监测其肝功能指标变化。结果:肝炎肝硬化组摄取高峰时间、平均残存指数均显著高于正常组(P<0.01),摄取指数、摄取速度指数、排泄速度指数均显著降低(P<0.05)。大黄虫丸治疗后肝炎肝硬化患者转氨酶、胆红素、球蛋白等肝功能生化指标均明显降低(P<0.01)。患者肝细胞的摄取高峰时间显著缩短,摄取指数均显著提高,(P<0.01);摄取速度明显提高(P<0.05);肝细胞平均残留指数显著降低(P<0.01)。结论:大黄虫丸不仅可改善肝炎肝硬化患者肝功能状态,还可提高患者肝细胞摄取和排泄功能。

Objective： To evaluate the influence of Chinese drug Dahuang Zhechong pill on the hepatocellular function. Method： Thirty-seven patients with hepatocirrhosis and twelve normal controls were performed the hepatobiliary scintgraphy with Tc-99m labeled ethylene hepatobiliary iminodiacetic acid （ 99m^Tc-EHIDA）, and the biochemical examination of hepatic function. There was 19 cases repeated the imaging after 6 months treated with chineses drug. By the three compartmental model configurations, the function parameters of hepatocellular extraction and excretion were calculated. Result： In the hepatoeirrhosis groups, the hepatocellular uptake peak time and mean residence index were higher than those in normal controls （P 〈 0. 01 ）. Compared to normal controls, the uptake index, uptake speed index and descendent speed index were decreased markedly （P 〈0. 05）. After treatment for 6 months with Chinese drug, the level of serum transaminase, globulin and bilirubin was lower than that before treatment. The uptake peak time and mean residence index decreased notably after treatment for 6 months （P 〈 0. 01 ）, and the uptake index increased, （P 〈 0. 05 ）. Conclusion ： Chinese drug Dahuang Zhechong pill may improve the hepatocellular function and liver function status in patients with hepatocirrhosis.