银屑病带状疱疹患者血浆芳香族氨基酸及支链氨基酸含量测定

INVESTIGATION OF THE PLASMA AAA AND BCAA IN PATIENTS WITH PSORIASIS AND HERPES ZOSTER

应用高效液相色谱法(HPLC)检测了58例寻常型银屑病患者及带状疱疹患者血浆芳香族氨基酸(AAA,包括苯丙氨酸、酪氨酸)及支链氨基酸(BCAA,包括亮氨酸、异亮氨酸、缬氨酸)的含量,结果显示带状疱疹患者血浆AAA、BCAA与正常对照组相比差异无显著性,初步认为带状疱疹与肝损害之间无明显关系;而银屑病患者血浆AAA、BCAA均高于正常人,差异有显著性,提示银屑病患者存在蛋白代谢障碍并可能存在肝脏的改变。

Aromatic amino acids(AAA including PHE and TYR)and branched - chain amino acids(BCAA including LEU, ILE and VAL)were analysed with HPLC in patients with psoriasis vulgaris and herpes zoster. The result showed that plasma AAA and BCAA of herpes zoster group were not of statistically significant difference compared with normal control group while the plasma AAA and BCAA of psoriasis group were significantly higher than those of normal control group. It was suggested that hepatic disorder may be present in psoriatic patients and there is no relationship between herpes zoster and hepatic disorder.