钙信号在光动力疗法中的产生及作用

Generation and Regulation Mechanism of Calcium Signal in Photodynamic Therapy

光动力疗法是基于光敏剂选择性地积聚在肿瘤组织中,肿瘤接受光照后凋亡或坏死的一种细胞毒性治疗方法。光敏剂的亚细胞定位决定了细胞光敏损伤的初始位置,线粒体、内质网、细胞膜、溶酶体、细胞骨架等均可成为光敏损伤的靶点。细胞内Ca2+作为一个广泛意义上的信号分子,参与了多种信号转导途径,在光动力疗法诱导肿瘤细胞凋亡过程中起了重要作用。从光动力疗法造成的亚细胞损伤出发,探讨了光动力疗法中钙信号的产生机制,并简要介绍了钙信号在光动力疗法诱导肿瘤细胞凋亡中的作用机制。

Photodynamic therapy （PDT） is a novel and promising treatment for cancer. Based on injection of a photosensitizer, followed by exposing the cancer to high dosage of light at an appropriate wavelength, then photosenzitizer accumulated in cancer initiates photodynamic reaction to destroy the cancer. Subcellular distribution of different photosenzitizers is different, any organelle can be the target of photosenzitizer, such as mitochondria, endoplasmic reticulum, plasma membrane, lysosome, cytoskeleton and so on. Organelles accumulated photosenzitizers would be firstly destroyed when illumination. As an important signal molecule, calcium signal is involved in the cellular signal transduction procedure and plays an important role in PDT-induced apoptosis. In this study, the generation mechanism of calcium signal was explored from the damnifications of subcellular, and then the regulation mechanism of calcium signal in apoptosis induced by PDT was elucidated concisely.