肝素酶与肿瘤发生发展的研究进展

Association between heparinase and tumors

肝素酶(heparanase,Hpa)是一种糖苷内切酶,可特异性地降解硫酸肝素,破坏细胞外基质和血管基底膜的完整性,释放结合于硫酸肝素上的生长因子、酶类分子等生物活性分子,促进细胞增生和微血管的生长,使肿瘤易于生长转移。国内外的大量研究已证明了肿瘤组织中肝素酶异常高表达,而抑制肝素酶的活性或表达可明显抑制肿瘤的生长、转移和血管发生。

Heparanase,a mammalian cell endoglucuronidase, degrades heparan sulfate （HS） at specific intrachain sites. HS is a major constituent of the extracellular matrix （ECM） and basement membranes （BMs）, the cleavage of which can affect the integrity and functional state of ECM and BMs. Apart from its direct contribution to ECM degradation, degradation of HS can release and activate HS-binding bioactive molecules such as growth factors, chemotactic factors, and enzymes which can accelerate cell growth and angiogenesis. Thus, heparanase may play important roles in invasion, metastasis and angiogenesis of tumors.