颈动脉斑块超声造影的显像特征与血浆MPO浓度关系的研究

Study on the relationship between the imaging performance of carotid atherosclerotic plaques with contrast-enhanced ultrasonography and myeloperoxidase (MPO) plasma concentration

目的通过对颈动脉粥样斑块实时超声造影的显像特征与血浆髓过氧化物酶(MPO)浓度的关系的研究,来评价颈动脉粥样斑块的稳定性。方法对73例颈动脉粥样硬化患者的73处斑块行实时超声造影检查,观察其显像特征,将其分为造影增强组与非增强组,根据二维超声中斑块回声的特征将造影增强组分为软斑组和混合斑组,比较两组斑块内造影剂增强持续时间、血浆MPO浓度的差异,并分析其造影剂到达时间、造影剂增强持续时间、血管内造影剂到达时间、血管内造影剂增强持续时间与血浆MPO浓度的相关性。结果与混合斑组相比,软斑组造影剂增强持续时间、血浆MPO浓度均显著高于混合斑组(P<0.01),并且斑块造影剂增强持续时间与血浆MPO浓度呈高度正相关,相关系数为0.877。结论颈动脉粥样斑块内造影剂增强持续时间、血浆MPO浓度均与斑块性质有关,提示其有助于全面评价粥样斑块的稳定性。

Objective In order to evaluate the plaques＇ stability, we investigated the relationship between the imaging performance of carotid atherosclerotic plaques with real-time contrast-enhanced ultrasonography （CEUS） and MPO plasma concentration. Methods To examine 73 cases with 73 carotid atherosclerotic plaques by real-time CEUS, and observe the imaging features of plaques. According to the imaging features, the 73 cases were divided into two groups （soft plaque group and mixed plaque group）, and analyze the differences of contrast medium （CM） persistently enhancement time in plaques and MPO plasma concentration between the two groups. Then analyze the dependability of the CM arriving-time in plaques, CM persistently enhancement time in plaques, the CM arriving-time in vasa sanguinea, CM persistently enhancement time in vasa sanguinea and MPO plasma concentration. Results Compared with mixed plaque group, CM persistently enhancement time and MPO plasma concentration in soft plaque group were significantly higher than that in mixed plaque group （P〈0.01）, and it is positive correlation between the CM persistently enhancement time and MPO plasma concentration, the correlation coefficient is 0.877. Conclusion These findings suggested that the CM persistently enhancement time in carotid atherosclerotic plaques and MPO plasma concentration are related with the property of the plaque, which can overall evaluate the plaques stability.