花椒毒酚的药效学研究──Ⅲ镇痛作用

An Experimental Study for the Analgesic Effect of Xanthotoxol

花椒毒酚（ｘａｎｔｈｏｔｏｘｏｌ，ＴＸ）是从蛇床子中提取的一种呋喃香豆素。ＸＴ明显抑制醋酸引起的小鼠扭体反应。ＸＴ显著提高热板法致痛小鼠的痛阈，此作用不被阿片受体拮抗剂纳络酮所拮抗。此外，ＸＴ明显降低大鼠角叉菜胶足跖炎症组织内ＰＧＥ含量。这些结果表明ＸＴ确有镇痛作用，其镇痛机制涉及抑制ＰＧ的合成而非激动阿片受体。

Xanthotoxol (XT) was a furan-coumarin isolated from the fruits of Cnidium monnieri (L.) Cusson.XT obviously inhibited the activities on mouse writhing induced by HOAc. XT markedly increased the pain threshold induced by the hot plate in mice and naloxone,the antagonist of opiate receptors didn’t reverse such an analgesic effect.Furthermore,XT decreased the contents of prostaglandin E in inflammatory tissue of rat hind paws induced by carrageenan.These results indicated that XT had an analgesic effect and that its analgesic mechanism was related to inhibiting the synthesis of prostaglandins ,rather than to agonizing opiate receptors.