白细胞血小板凝集在中风病急性期的变化及与中医证候相关性的研究

Changes of WBC platelet agglomeration in stroke in acute seizure phase and correlation between these changes and TCM syndromes

目的探讨白细胞血小板凝集在中风病急性期的变化及与中医证候的相关性。方法检测中风急性期患者在发病1周内和第14天时的白细胞血小板凝集,同时予中医证候评分,进行白细胞血小板凝集在两时点的描述性统计和差异性检验,并研究两时点白细胞血小板凝集与中医证候的相关性。结果男性患者白细胞血小板凝集在发病1周内和第14天有统计学差异(P<0.05)。在发病1周内,白细胞血小板凝集在男性与女性间存在统计学差异(P<0.05),并与火热证有相关性(P<0.05),且其在火热证成立者与未成立者间存在统计学差异(P<0.05);发病1周内和第14天白细胞血小板凝集的差异与风证分值差异有相关性(P<0.05)。结论在中风发病1周内,白细胞血小板凝集大部分处于正常或抑制状态,男性比女性相对受到抑制,火热证成立者相对受到抑制;第14天时,风证变化越明显则白细胞血小板凝集变化越不明显。

Objective To investigate the changes of WBC platelet agglomeration in stroke in acute seizure phase and the correlation between these changes and TCM syndromes. Methods WBC platelet agglomeration was detected respectively whin 1 week and on the 14th day after stroke invasion, and at the same time the patients were evaluated with TCM syndrome scores. The descriptive statistics and different test were given to the patients at two time points and the research was conducted on the correlation between WBC platelet agglomeration at two time points and TCM syndromes. Results In male patients there was a statistic difference in WBC platelet agglomeration within 1 week and on the 14th day （P〈0.05）. Within 1 week there was a statistic difference in WBC platelet agglomeration between male and female patients （P〈0.05）. WBC platelet agglomeration was correlated to the syndrome of fire-heat within 1 week （P〈0.05）. There was a statistical difference between the patients suffered from the fire-heat syndrome and those did not suffer from the fire-heat syndrome （P〈0.05）. The differences of WBC platelet agglomeration within 1 week and on the 14th day were correlated to the difference of the score value of the fire-heat syndrome （P〈0.05）. Conclusion Within 1 week after stroke invasion WBC platelet agglomeration mostly was normal or inhibited, which was inhibited more in male than in female patients, and more in the patients suffered from the fire-heat syndrome. On the 14th day the more the fire-heat syndrome changed, the less the WBC platelet agglomeration changed.