蒿甲醚固体分散体缓释制剂的研制及其体外溶出度的观察

Preparation of Sustained Release Agent of Artemether Solid Dispersion and Determination of Its Dissolubility in Vitro

本实验以肠溶材料丙烯酸树脂Ⅱ号为载体制成蒿甲醇的固体分散体。X射线衍射实验表明，药物与载体比例为1：2和1：3时，药物在固体分散体中改变了晶型。体外溶出实验说明，固体分散体在pH0．8人工肠液中溶出量较蒿甲醚原粉大为增加。结果表明：蒿甲醚固体分散体缓释制剂既可增加溶解度，提高药物的生物利用度，又达到缓释的目的。

The artemether solid dispersion was prepared by using Eudragit II as carrier.The X-ray diffraction examinationshowed that the crystal pattern of artemether in the solid dispersion was changed when the ratio of artemether to carrier was 1:2 or1:3.The dissolubility of artemether solid dispersion in PH 6.8 miditun was higher than that of artemether powder.The results indicatethat the dissolubility and bioavilability of artemether in the solid dispersion can be increased and sustained release behaviour canbe obtained as well.