吸入型药物在哮喘治疗中的应用

Application of inhalants in treatment of asthma

类固醇和β受体兴奋剂是治疗哮喘的常用药。吸入给药可使气道局部药物i浓度高而血液中药物浓度低。可有效地抑制气造高反应．解除气道痉挛，而全身副反应少。类固醇的吸入应尽早开始，并根据病情调整用量，坚持长期使用。而β受体兴奋剂则应按需吸入，不宜长期、有规律地使用。

The goals of drug therapy for asthma are reduction of airway inflammation and prevention of bronchospasm caused by airway hyperresponsiveness. Steroids and 5-agonists are widely used in the treatrnent of asthma. Inhalant drugs rnay provide a high concentration of drugs in local airway,while plasmatic concentrations 0f drugs is l0wer. Inhalants can effectively inhibite airway hyperresponse and relax airway spasm,in the rneantime it has less side effects. Early usage of inhant steroids is suggested and adjustrnent of dosage is necessary according to the clinical cases. Inhalant drugs may be used for a long period, however, β-agonists rnust be inhalated if necessary. Long-term and regular use of β-agonists is not recommended.