纳洛酮治疗肝性脑病的疗效观察

The Study on Therapeutic Effects of Naloxone on Patients With Hepatic Encephalopathy

目的研究纳洛酮治疗肝性脑病的疗效。方法肝性脑病患者42例,随机分为两组,治疗组21例,对照组21例。治疗前、后测定患者血清氨的含量,并观察纳洛酮对肝性脑病疗效。结果肝性脑病患者血氨含量明显增加,且与肝性脑病程度相关。纳洛酮治疗后血氨含量下降程度和肝性脑病清醒时间明显优于对照组,两组相比具有显著性差异(P<0.05)。结论纳洛酮对肝性脑病具有明显疗效。

Objective To investigate the therapeutic effects of naloxone on patients with hepatic encephalopathy. Methods Forty- two patients with HE were divided into two groups： treatment group（21 cases）, control group（21 cases）. Serum levels of NH3 was examined in all pa tients before and after treatment. The clinical efficacy was also observed. Results Serum levels of NH3 increased markedly in HE and correlated with the severity of HE. The decreased serum NH3 level and the time of regaining consciousness were superior to that in the control group（P〈 0.01 ）, and the side effects were slight. Conclusion The naloxone is a beneficial agent in treatment of hepatic encephalopathy safely.