超敏C-反应蛋白检测在脑卒中的应用价值

The Value of hs-CRP Detection in patients with Cerebrovascular Disease

目的探讨hs-CRP检测在脑卒中诊断和治疗中应用的价值。方法选择脑卒中病患者共68例,其中脑梗死组36例,脑出血组32例,正常对照组35例作为研究对象。hs-CRP测定采用颗粒增强免疫透射比浊法,并对hs-CRP进行统计学比较和ROC分析,分析hs-CRP与脑卒中的关系。结果脑卒中组hs-CRP水平均明显高于正常对照组(P<0.001),脑梗死组与脑出血组间比较差异无显著性(P>0.05);同时通过临床观察发现hs-CRP水平相对高者病情转归及预后差,相对低者病情转归及预后良好。相关分析结果显示,hs-CRP含量与常规检验指标(空腹血糖、甘油三酯、总胆固醇、低密度脂蛋白胆固醇)均呈显著正相关(P<0.01);与高密度脂蛋白胆固醇水平呈显著负相关(P<0.01)。结论hs-CRP水平升高与急性脑卒中患病呈显著相关,对脑卒中的诊断及预后判断具有临床价值。

Objective To discuss the content changes of high sensitive C-reactive protein （hs-CRP）and its influence on prognosis of the cerebrovascular disease. Methods hs-CRP level of 36 patients with cerebrovascular infarction and 32 patients with intracerebral hemorrhage were measured,35 cases of normal health examination were selected as a control group. Detecting the hs-CRP in CVD patients and in control group by particle-enhanced turbidimetric immunoassay（PETIA）technique,then analyzing the data with t-test and ROC curves. The correlation between hs-CRP and the cerebrovascular disease were analyzed. Results There was significant difference in the serum level of high sensitive C-reactive protein between the CVD group and the control group （P〈0.01）. There was no significant difference of hs-CRP level between cerebrovascular infarction group and intracerebral hemorrhage group（P〉 0.05）,and strong positive correlations were observed between the hs-CRP level and systolic pressure, the serum fasting blood glucose, total cholesterol, triglyeerides, LDL-C and HDL-C by analysis using the multivariate stepwise regression model （all P 〈0.01）. Conclusion High sensitive C-reactive protein as a risk factor for CVD,and hs-CRP has a strong association with CVD, and it is regarded as an indication for the prognosis of CVD.