刺五加注射液用于心肌缺血非心脏手术病人的临床观察

Effect of Acanthopanax Injecta on Myocardial Ischemia Patients with Noncardiac Surgery

目的观察刺五加注射液应用于心肌缺血病人非心脏手术时心肌缺血改善的有效性。方法选择非心脏手术心肌缺血病人50例,随机分为刺五加组(Ⅰ组)和对照组(Ⅱ组),于麻醉前、麻醉后20min、40min、60min时对ECG、HR、ST段、MAP及RPP进行对比观察。结果Ⅰ组病人静滴刺五加注射液后20minECG的ST段开始出现明显改善,40min后ST段变化趋于稳定;Ⅱ组病人ECG无明显变化。两组ECG的ST段变化有极显著性差异(P<0.01)。术中Ⅰ组HR、RPP均有所下降;对照组HR明显增快(P<0.01)。结论刺五加注射液能够改善心肌缺血病人非心脏手术时心肌供血状况。

Objective To study the effect of acanthopanax injecta on the patient with myocardial ischemia undergoing noncardiac surgery. Methods 50 patients with myocardial ischemia undergoing nonc ardiac surgery were randomly divided in two groups： acanthopanax injecta group （Group Ⅰ ） and control group （Group Ⅱ ）. ECG, HR, ST segment, MAP and RPP were measured before anesthesia,20min,40min and 60min after anesthesia. Results ST segment began to improve 20min after anesthesia and tended to stabilize 60min after anesthesia in Group Ⅰ . No significant change was observed in Group Ⅱ. The changes of ST segment were significant different between Group Ⅰ and and Group Ⅱ （P〈0.01）. Both HR and RPP decreased during surgery in Group Ⅰ , while HR increased in Group Ⅱ. Conclusion Myocardial ischemia can be improved by acanthopanax injecta.