糖尿病胰岛素及胰岛β细胞功能的研究

Study on the Function of Insulin and β-cell in Newly Diagnosed Patients

目的比较新诊断的老年2型糖尿病患者与中年2型糖尿病患者胰岛素抵抗及胰岛β细胞功能。方法将113名40岁以上新诊断的T2DM患者分为两组,其中40～59岁(中年组)64例,60岁以上(老年组)49例。分别测量体质指数、腰臀比、检测口服葡萄糖耐量试验、甘油三酯、总胆固醇,观察指标为OGTT各点血糖和胰岛素,根据血糖和胰岛素计算HOMA-IR、HOMA-IS、△Ins30/△Glu30等。结果新诊断老年组OGTT 2～3h血糖高于中年组同点血糖(P<0.05),老年组OGTT 2～3h胰岛素值高于中年组同点胰岛素值(P<0.05)。老年T2DM患者与中年T2DM患者相比HOMA-IR、HOMA-IS、△Ins30/△G lu30均有明显差异。结论与中年发病的糖尿病患者相比,老年2型糖尿病患者在胰岛素抵抗及胰岛素早期分泌缺陷方面有明显的差异。

Objective To compare diversity of insulin resistance and β -cell function between senile and middle age patients with newly diagnosed type 2 diabetes. Methods 113 newly diagnosed adults（aged from 40 to 77 years old） with type 2 diabetes were divided into two groups, in senile age group the patiens were aged from 60 to 77 years old,in middle age group the patients were aged from 40 to 59 years old. BMI, wait-hip ratio,TG,TC, OGTT Were detected. HOMA-IR, HOMA-IS and △Ins30/△Glu30 after OGTT were calculated. Results Compared with middle age group, the senile group had higher values of HOMA-IR [（ 1.56 ± 0.46 ）vs （ 1.42 ± 0.34 ）, P 〈 0.05], OGTF 2-3h plasma glucose [（ 16.17 ± 3.03 ）vs （ 13.42 ± 2.79 ）, P 〈 0.05]and postprandial insulin secretion [（75.32 ± 37.23 ）vs （66.22 ± 35.89 ）, P 〈 0.05]. But the BMI,TC,TG,LDL, HDL, △I30/△G30[（2.62 ± 0.43 ）vs （3.37 ± 0.58 ）,P 〈 0.05]and C-peptide[（5.43 ± 1.23 ）vs （8.86 ± 1.62 ）,P 〈 0.01] were lower in the senile group vs in middle age group. Conclusion Compared with middle age group, the senile group has obvious insulin resistance and insulin secretion.