米索前列醇不同用药途径中期妊娠引产的效果观察

Observation of Curative Effect of Misoprostol Given by Different Ways for Odinopoeia during Metaphase Pregnancy

目的探讨米非司酮配伍米索前列醇不同用药途径终止10～18周妊娠的效果。方法300例中期妊娠孕妇,随机分为三组:A组100例,米非司酮配伍米索前列醇口服用药;B组100例,米非司酮口服,米索前列醇阴道给药;C组100例,米非司酮口服,米索前列醇直肠给药。结果三组引产后2h内出血量无统计学意义(P>0.05),但B、C组引产成功率较A组高,引产时间较A组缩短,差异具有显著性(P<0.05);B、C组间无差异性(P>0.05)。结论米非司酮口服配伍米索前列醇局部用药终止中期妊娠优于米非司酮联合米索前列醇口服用药,其中米索前列醇直肠给药更方便、快捷。

Objective To prode into the curative effects of misoprostol combined with mifepristone given by different ways for odinopoeia during pregnancy from 10 to 18 weeks. Methods 300 cases of pregnant women were randomly divided into groups A, B and C with 100 cases for each. For group A by oral-taking misoprostol combined with mifepristone; Group B by oral-taking mifepristone and misoprostol by vagina; Group C by oral-taking mifepristone and misoprostol by rectum. Results It made no sense on statistics on flooding two hours after odinopeia（P〉0.05）, but the successful rates of odinopoeia of groups B and C were higher than group A, and the odinopoeia time was shorter than group A; The difference is prominence（P〈0.05） but there was no difference between groups B and C（P〉 0.05 ）. Conclusion To give misoprostol combined with mifepristone locally is better for stopping metaphase pregnancy than by giving misoprostol combined with mifepristone orally, where by giving misoprostol by rectum will be more convenient and rapid.