下呼吸道肠出血性大肠杆菌感染的相关因素临床探讨

Clinical Study on Relative Factors of Lower Respiratory Tract Enterohemorrhagic Escherichia Coli Infection

目的探讨ICU大量应用抗生素致下呼吸道EHEC感染的相关因素。方法100例感染者标本采用Kirby-Bauer法测定临床分离菌株对抗生素的耐药性,采用Logistic多因素回归分析方法进行统计学处理。结果患者的年龄、住院天数、基础疾病、侵袭性操作、抗菌药物和免疫抑制剂使用等与医院内下呼吸道大肠埃希菌EHEC感染皆具有显著相关性。结论及早发现、及早确诊、及时治疗是改善预后、降低院内下呼吸道大肠埃希菌EHEC感染病死率的重要手段。

Objective To investigate the relative factors of lower respiratory tract enterohemorrhagic escherichia coli infection after applied many antibiotics in ICU. Methods The drug resistance to antibiotics of 100 patients＇samples were detected by Kirby-Bauer method, and statistical treatment used by Logistic multiple factor regression analysis. Results There was significant difference between age, hospital day,primary disease,invasive manipulation, antibacterials, immune depressant and lower respiratory tract enterohemorrhagic escherichia coli infection. Conclusion Early discovery, early diagnosis and prompt treatment are important means to improve prognosis and decrease mortality of lower respiratory tract enterohemorrhagic escherichia coli infection in hospital.