期刊文献+

他汀类药物在多发性硬化治疗中的研究进展(综述) 被引量:7

下载PDF
导出
摘要 大量研究证实他汀类药物具免疫调节、抗炎和神经保护作用,且可与不同机制的免疫调节剂联用协同治疗多发性硬化(MS),由此可预见其在治疗MS中具广阔前景。该文就他汀类药物在MS中可能的作用机制研究进展做一综述。
作者 邓艳 张旭
出处 《中国神经免疫学和神经病学杂志》 CAS 2008年第2期112-115,共4页 Chinese Journal of Neuroimmunology and Neurology
  • 相关文献

参考文献16

  • 1Kobashigawa JA, Katznelson S, Laks H, et al Effect of pravastatin on outcomes after cardiac transplantation[J]. N Engl J Meal,1995,333:621-627.
  • 2Youssef S, Stuve O, Patarroyo JC, et al. The HMGCoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous systern autoimmune disease [J]. Nature, 2002, 420.- 78- 84.
  • 3Aktas O, Waiczies S, Smorodchenko A, etal. Treatment of relapsing paralysis in experimental encephalomyelitis by targeting Thl cells through atorvastatin [J]. J Exp Med, 2003,197:725-733.
  • 4Nath N, Giri S, Prasad R, et al. Potential targets of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor for multiple sclerosis therapy [J]. J Immunol, 2004,172-1273 1286.
  • 5Neuhaus O, Strasser-Fuchs S, Fazekas F, et al. Statins as immunomodulators: comparison with interferon-beta lb in MS[J]. Neurology, 2002,59.- 990-997.
  • 6Peng X, Jin J, Girl S, et al. Immunomodulatory effects of 3-hydroxy 3 methylglutaryl coenzyme A reductase inhibitors, potential therapy for relapsing remitting multiple sclerosis [ J ]. J Neuroimmunol, 2006,178: 130-139.
  • 7Dunn SE, Youssef S, Goldstein MJ, et al. Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity byatorvastatin[J]. J Exp Med, 2006,203:401 -412.
  • 8Vollmer T, Key L, Durkalski V, et al. Oral simvastatin treatment in relapsing-remitting multiple sclerosis[J]. Lancet, 2004,363 : 1607-1608.
  • 9Zeinstra E, Wilczak N, Chesik D, et al. Simvastatin inhibits interferon gammanduced MHC class Ⅱ upregulation in cultured astrocytes[J]. J Neuroinflamma tion,2006,3:16.
  • 10Liao JK. Isoprenoids as mediators of the biological effects of statins[J]. J Clin Invest, 2002,110:285 -288.

同被引文献95

引证文献7

二级引证文献11

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部