摘要
目的研究CT灌注成像对慢性阻塞性肺疾病(COPD)的诊断价值。方法20例COPD患者和20例志愿者行8层螺旋CT灌注成像,采用电影扫描(cine)方式,层厚5mm,扫描时间0.5s/层,注射对比剂后延时5s,总扫描时间为45s,测量感兴趣区血流量、血容量、平均通过时间及表面通透性和时间-密度曲线。结果COPD患者的时间-密度曲线较志愿者曲线平坦,峰值明显降低。COPD患者血流量[(24.77±11.49)ml·min^-1·100g^-1]、血容量[(2.48±1.02)ml/100g]及表面通透性[(2.75±1.13)ml·min^-1·100g^-1]明显低于志愿者[血流量(290.14±107.59)ml·min^-1·100g^-1、血容量(16.51±5.98)ml/100g、表面通透性(8.80±3.03)ml·min^-1·100g^-1];平均通过时间[(10.58±4.85)s]高于志愿者[(4.50±1.71)s],差异均具有统计学意义(P〈0.01)。结论多层螺旋CT肺灌注扫描对COPD的诊断有一定的辅助作用。
Objective To evaluate the diagnostic value of multi-slice spiral CT (MSCT) perfusion imaging in chronic obstructive pulmonary disease (COPD). Methods Twenty COPD patients and 20 volunteers underwent 8-row detector spiral CT (MSCT) perfusion imaging using eine scan mode with 5 mm slice thickness, 0. 5 s rotation time and a total scan time of 45 s with 5 s intervals. 60 ml contrast agent (300 mg I/ml) were administered at a rate of 4 ml/s from the forearm superficial vein. The imaging data were transferred to a workstation. A time-density curve and pseudo-color map were generated automatically with GE CT perfusion 3 software, the blood flow (BF), blood volume (BV), mean transit time (MTT) and permeability surface (PS) were measured. Results Time-density curve was flatter and the peak of the curve was obviously lower in COPD patients than the volunteers. The BF, BV, PS in COPD patients was (24.77 ±11.49) ml ·min^-1· 100 g^-1, (2.48 ±1.02 ) ml/100 g and (2.75 ±1.13) ml ·min^-1· 100 g^-1 respectively. In volunteers was (290. 14 ±107. 59)ml ·min^-1· 100 g^-1, ( 16. 51 ± 5.98) ml/100 g, (8.80 ±3.03) ml ·min^-1· 100 g^-1 respectively. The MTr in COPD patients and volunteers was (10. 58 ±4. 85) s and (4. 50 ± 1.71)s respectively. The BF, BV and PS in COPD patients was lower than the volunteers, the MTr was higher ( P 〈 0. 01 ). Conclusion MSCT perfusion imaging is helpful for the diagnosis of COPD.
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2008年第3期281-284,共4页
Chinese Journal of Radiology