毫米波治疗颈部急性放射性溃疡的临床观察

Clinical observation of the effect of millimeter-wave in the treatment of acute radiation-induced neck skin ulcers

目的评价毫米波（MMW）治疗颈部急性放射性皮肤溃疡的临床疗效和不良反应，探求治疗急性放射性皮肤溃疡新途径。方法采用随机对照研究，将54例鼻咽癌根治性放疗后颈部急性放射性溃疡的患者随机分为毫米波组（MMW组）和对照组，MMW组给予毫米波治疗和常规治疗，对照组接受毫米波安慰性治疗和常规治疗。比较2组患者溃疡愈合情况和愈合时间。结果MMW组与对照组颈部急性放射性溃疡有效率分别为92．86％（26／28）和65．38％（17／26），差异有统计学意义（P〈0．05）；MMW组与对照组皮肤溃疡愈合时间分别为（14．30±2．41）d和（25．33±2．00）d，差异有统计学意义（P〈0．01）。结论MMW治疗可有效促进急性放射性溃疡的伤口愈合，加速放射性皮肤溃疡的愈合时间。

Objective To evaluate the efficacy of millimeter-wave （MMW） in the treatment of acute radiation-induced skin ulcers and to observe the adverse events. Methods Fifty-four patients with nasopharyngeal neoplasm complicated with acute neck skin ulcers induced by radical radiotherapy were randomly divided into two groups, a treatment group of 28 cases treated with MMW and routine therapy, and a control group of 26 cases treated with routine-therapy and placebo MMW therapy. The efficacy of MMW, adverse events, and the healing time were recorded and compared. Results It was shown that the effective rate was higher in the treatment group than that in the control group （92.86% vs 65.38% ,P 〈0.05）. Moreover, the healing time of the acute radiation-induced skin ulcers was （ 14.30 ±2.41 ） and （ 25.33±2.00） days in the treatment and control groups, respectively, with a significant difference between them （P 〈0.01 ）. Conclusion It was concluded that MMW could be a safe and effective option for treating acute radiation-induced skin ulcer.