血清脂联素水平与老年人代谢综合征的相关性

Serum adiponectin level declines in the elderly with metabolic syndrome

目的 通过横断面研究，评估血清脂联素水平与老年人代谢综合征的相关性。方法检测61例代谢综合征患者和140例非代谢综合征老年人血清脂联素、C反应蛋白、血糖、胆固醇、三酰甘油、高密度脂蛋白、低密度脂蛋白等，通过Logistic回归分析评价血清脂联素水平与老年人代谢综合征的关系，并采用等级相关统计方法比较血清脂联素水平。结果代谢综合征患者血清脂联素为（7．2±3．6）g／L，低于非代谢综合征组（10．0±3．9）g／L，代谢综合征1级、2级、3级的患者分别为27例（44．3％）、21例（34．4％）和13例（21．3％），脂联素水平分别为（8．5±2．7）g／L、（7．0±2．5）g／L和（4．9±2．4）g／L，随着代谢综合征组分的增多，脂联素的含量呈下降趋势，两两比较呈等级相关（均为P〈0．01）。Logistic回归分析显示，在校正了年龄、体质指数和性别比后，高水平脂联素使代谢综合征患病风险降低。脂联素四分法表示中，高脂联素水平组患代谢综合征的风险较其他较低组降低96．0％（OR=0．04，95％可信区间0．023-0．056，P〈0．01）。结论老年人中，高水平脂联素使代谢综合征患病风险降低。

Objective To investigate the correlation between serum adiponectin level and metabolic syndrome in the elderly. Methods Sixty-one subjects with metabolic syndrome and 140 age-and sex-matched subjects without metabolic syndrome were recruited in the study. Samples were analyzed for adiponectin, C-reactive protein, blood glucose, cholesterol, triglyceride, low density lipoprotein and high density lipoprotein, etc. Logistic regression analysis was used to evaluate the correlation between metabolic syndrome and serum adiponectin level. Results Adiponectin level was lower in subjects with metabolic syndrome than in subjects without metabolic syndrome [（7. 2±3.6）g/L vs. （10.0±3. 9）g/L]. The serum adiponectin level was declined with the increase of components of metabolic syndrome[ （8.5±2. 7） g/L in grade 1 metabolic syndrome; （7. 0 ± 2. 5） g/L in grade 2 metabolic syndrome; （4. 9±2.4） g/L in grade 3 metabolic syndrome]. The serum level of adiponectin was not decreased in non-metabolic syndrome subjects with any single component of metabolic syndrome. Logistic regression analysis showed high level of adiponectin prevents the subjects from metabolic syndrome. The upper quartile adiponectin decreased about 96% incidence of metabolic syndrome compared with the lower quartile adiponectin（OR = 0. 04,95 % CI 0. 023-0. 056, P〈0. 01）. Conclusions High level of serum adiponectin prevents the elderly from metabolic syndrome.