我院50例肝移植患者术后早期抗感染药应用及合理性分析

Postoperative Use of Anti-infective Agents in 50 Inpatients Undergoing Liver Transplantation and Its Rationality

目的:评价我院器官移植中心肝移植患者术后早期抗感染药的应用情况及合理性。方法:调查我院2005年9～12月50例肝移植患者术后1月内抗感染药的应用状况,结合其应用例/次、应用时间、药物利用指数(DUI)及药物联用与病原学相符情况,分析其应用的合理性。结果:肝移植术后1月内应用频率列前10位的抗感染药中,DUI≤1的有9个,DUI>1的1个;围手术期抗菌药物应用率达100%;联合用药中,单用2例(占4%),二联应用17例(占34%),三联应用21例(占42%),四联以上应用10例(占20%)。结论:我院术后抗感染药应用剂量和联合用药比例均偏高,亟待干预。

OBJECTIVE： To study the postoperative use of anti- infectives inpatients undergoing liver transplantation and its rationality. METHODS： 50 inpatients who had undergone liver transplantation were randomly collected from center of organ transplantation for the analysis of the use of anti- infective agents within 1 month after operation in respect of utilization frequency （cases/times）, duration of medication, drug utilization index （DUI） as well the conformity between drug combination and etiology so as to derive the rationality of drug use. RESULTS： Among the top 10 anti - infectives in terms of utilization frequency in patients undergone liver transplantation, 9 had their DUI less than 1, and 1 had its DUI above 1. The perioperative application rate of anti - infective agents was 100%. In terms of drug combination, 2 cases （4%） used one kind of anti- infectives, 17 （34%） two kinds, 21 （42%） tree kinds, 10 （20%） four kinds concomitantly. CONCLUSION： The doses and the proportion of anti-infectives used in combination for inpatients undergoing liver transplantation were on the high side, which should be controlled urgently.